Chelate derivatives of atrial natriuretic factor (ANF)
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United States of America Patent
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Sep 28, 1993
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app pub date -
Feb 27, 1992
filing date -
Jun 16, 1989
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Abstract
Derivatives of synthetic fragments of mammalian atrial natriuretic factor (ANF) in which a chelate molecule is attached to the N-terminal of the peptide are described. The chelate component allows the facile labelling of these peptides with metallic isotopes such as Tc-99m, Ga-67, In-111 and others. These radioactive chelates are useful in determining the in vivo behavior and fate of derivatives of ANF.
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