N-imidazolyl derivatives of substituted indole
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United States of America Patent
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Sep 21, 1993
Grant Date -
N/A
app pub date -
Apr 17, 1992
filing date -
Apr 24, 1991
priority date (Note) -
Expired
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Abstract
The invention provides N-imidazolyl derivatives of substituted indole of general formula (I) ##STR1## wherein p is an integer of 1 to 4; A is a straight or branched C.sub.1 -C.sub.4 alkylene chain; B is a direct linkage, a straight or branched, unsaturated or saturated C.sub.1 -C.sub.4 hydrocarbon chain; Q is a straight or branched, saturated or unsaturated C.sub.1 -C.sub.9 hydrocarbon chain, or said chain is interrupted by an oxygen atom; each of R.sub.1 and R.sub.2 independently is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, halogen or trihalomethyl; each of R.sub.3 and R.sub.5, independently, is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sub.4 is a --OR.sub.6 or --N(R.sub.6 R.sub.7) group, wherein each of R.sub.6 and R.sub.7 independently is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or benzyl; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of a disease state in which an enhancement of TxA.sub.2 synthesis exerts a pathogenic effect.
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