Radioimmunotherapy using .alpha.-particles emission
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United States of America Patent
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Sep 21, 1993
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Feb 19, 1991
filing date -
Jun 19, 1989
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Abstract
The present invention relates to the use of Actinium or one of its daughters in radioimmunotherapy. Also provided are immunoconjugates comprising an isotope, a chelating agent and a slowly localizing antibody. The invention also includes pharmaceutical compositions comprising said immunoconjugates, as well as such compositions comprising one or more scavenging agents. The compositions according to the invention are particularly useful for the treatment of micrometastases in adjuvant therapy, as well as for treatment of localized tumors.
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