Exonuclease resistant terminally substituted oligonucleotides
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United States of America Patent
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Sep 14, 1993
Grant Date -
N/A
app pub date -
Aug 3, 1990
filing date -
Aug 3, 1990
priority date (Note) -
Expired
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Abstract
Compounds, compositions and methods for inhibiting gene expression are disclosed. The compounds comprise oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini. Preferred diols are polyalkyleneglycols, preferably polyethyleneglycols. Pharmaceutical compositions comprising the compounds and a physiologically acceptable carrier and methods of inhibiting gene expression in mammals comprising administering such compounds are also provided. Methods for inhibiting nuclease cleavage of compounds are also provided.
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