DNA coding for enzyme capable of acylating the 4"-position of macrolide antibiotic
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United States of America Patent
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Aug 31, 1993
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N/A
app pub date -
May 23, 1989
filing date -
May 24, 1988
priority date (Note) -
Expired
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Abstract
A DNA fragment containing acyB gene coding for an enzyme capable of acylating the 4'-position of a macrolide antibiotic, said DNA fragment being derived from a microorganism of the genus Streptomyces, having a size of about 3.1 kb and being characterized by the restriction endonuclease map shown in FIG. 1 , and a DNA restriction fragment resulting from digestion with a restriction endonuclease; a recombinant DNA plasmid containing this DNA fragment; a microorganism transformed with this recombinant plasmid; and a process for producing a 4'-acylated macrolide antibiotic by using the transformant.
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