Exopeptidase catalyzed site-specific bonding of supports, labels and bioactive agents to proteins
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United States of America Patent
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Aug 10, 1993
Issued Date -
N/A
app pub date -
Jun 28, 1990
filing date -
Jun 30, 1989
priority date (Note) -
Expired
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Abstract
An auxiliary substance such as a label, support, or bioactive agent is attached to a protein at a site that is remote from the active site of the protein by the use of exopeptidase and a nucleophile which is an amino acid, amino acid derivative, amine or alcohol. In one embodiment, the nucleophile is attached to the carboxy terminus of a protein by catalysis with exopeptidase to form an adduct and then the adduct or its combination with a linker arm is bound to the auxiliary substance. In another embodiment, the auxiliary substance or its combination with a linker arm is bound to the nucleophile to form an intermediate substance which is then coupled by catalysis with exopeptidase to the carboxy terminus of a protein.
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