Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset
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United States of America Patent
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Aug 10, 1993
Grant Date -
N/A
app pub date -
Aug 23, 1991
filing date -
Aug 23, 1991
priority date (Note) -
Expired
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Abstract
A delayed onset transdermal drug delivery device exhibiting a delay period of at least six hours comprising a laminated composite of (1) a top backing layer; (2) a pressure rupturable layer underlying (1); (3) a reservoir of a solution of drug in a liquid vehicle between (1) and (2); (4) a wick layer underlying (2) for dispersing the drug once (2) is ruptured; (5) a first adhesive layer underlying (4) that is permeable to the drug; (6) a microporous membrane underlying (5) which is itself impermeable to the drug and whose pores are substantially unfilled prior to application of the device to the skin; and (7) a second adhesive layer underlying (6) that is permeable to the drug but is immiscible in the polymer filling the pores of (6).
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