Method for the purification of intact, correctly-folded insulin-like growth factor-1
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United States of America Patent
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Jul 27, 1993
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app pub date -
Oct 28, 1991
filing date -
Jan 16, 1991
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Abstract
Method for the recovery and purification of intact, correctly-folded, monomeric insulin-like growth factor-1 peptide from large volumes of IGF-1-containing medium are described, comprising a series of adsorption-desorption steps employing a combination of cation exchange and hydrophobic interaction adsorbents. Product IGF-1 peptide is highly purified and suitable for use in a variety of clinical applications.
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