Immunoglobulin-binding polypeptides
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United States of America Patent
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Jul 27, 1993
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N/A
app pub date -
Sep 8, 1989
filing date -
Sep 8, 1989
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Expired
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Abstract
Polypeptides having a segment capable of binding to immunoglobulin heavy chain variable regions (V.sub.H) in an antigen independent manner have been described. These polypeptides can be used to form complexes with V.sub.M containing molecules for diagnostic purposes and to increase the affinity of the antibody for its antigen. Additionally, the polypeptides of the invention can be used to separate V.sub.H containing molecules from solution to form isolated V.sub.H or V.sub.H depleted compositions.
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