Recombinant Alzheimer's protease inhibitory amyloid protein and method of use

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United States of America Patent

PATENT NO 5223482
SERIAL NO

07361912

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Abstract

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DNA sequences encoding .beta.-amyloid-related proteins associated with Alzheimer's disease are disclosed. Also provided herein is a DNA sequence encoding a novel protease inhibitor. These sequences are used in producing or constructing recombinant .beta.-amyloid core protein, .beta.-amyloid-related proteins and recombinant or synthetic immunogenic peptides. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.

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Patent Owner(s)

Patent OwnerAddress
SCIOS NOVA INC6200 FREEPORT CENTRE BALTIMORE MD 21224-6522

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cordell, Barbara Palo Alto, CA 35 810
Ponte, Phyllis A Mountain View, CA 2 115
Schilling, Jr James W Palo Alto, CA 9 98

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