Electrophoretic mobility of fluorophore labeled particles in gels by fluorophore movement after photobleaching
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United States of America Patent
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Jun 1, 1993
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N/A
app pub date -
Jul 9, 1990
filing date -
Jul 9, 1990
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Expired
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Abstract
A process and apparatus for detecting the mobility of fluorescently labeled molecules in response to a force is disclosed. The fluorescently labeled molecules are placed in a fluid medium such as an electrophoretic gel in a capillary tube. An electric field is applied to induce the movement of the molecules. A region of the labeled molecules is photobleached leaving a geometrically defined region which has not been photobleached. The region which has not been photobleached is excited by a reading beam. The reading and the photobleaching beams can be generated by focusing a laser through a diffraction grading. The intensity produced by the interaction of the reading beam in the geometrically defined region of the molecule is detected by a photo detector. In detecting more than one sp This invention was partially made with Government support under the polymers program of the National Science Foundation DMR8617820. The Government has certain rights in the invention.
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