Long acting calcium channel blocker composition
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United States of America Patent
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May 11, 1993
Issued Date -
N/A
app pub date -
Sep 13, 1991
filing date -
Jan 10, 1990
priority date (Note) -
Expired
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Abstract
There is disclosed an improved long acting sustained release pharmaceutical composition for dihydropyridine calcium channel blockers wherein the calcium channel blocker and a pH-dependent binder, which are intimately admixed in essentially spherically shaped non-rugose particles of up to 1.2 mm in diameter, are provided with a coating to obtain slow, sustained release of a safe, therapeutically effective amount of the calcium channel blocker over a period of at least about 24 hours. Thus, the improved pharmaceutical composition for a dihydropyridine calcium channel blockers is suitable for once daily administration.
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