Production of chimeric antibodies by homologous recombination
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United States of America Patent
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Apr 20, 1993
Issued Date -
N/A
app pub date -
Sep 14, 1988
filing date -
Oct 27, 1987
priority date (Note) -
Expired
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Abstract
A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologous recombination occurs in the transfected cells leading to gene modification and the production of chimeric antibody molecules by the transfected cells.
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