Immunosuppressant-producing culture
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United States of America Patent
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Apr 13, 1993
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app pub date -
Mar 9, 1992
filing date -
Aug 5, 1988
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Abstract
Described is a new microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The microorganism acts as a demethylating agent and can produce the new immunosuppressants, 'demethomycin' (L-682,993) a C-31 demethylated analog of L-679,934, and 'demethimmunomycin' (L-683,742) a C-31 demethylated analog of L-683,590, under novel fermentation conditions. These macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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