Production of chimeric antibodies by homologous recombination
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United States of America Patent
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Apr 13, 1993
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N/A
app pub date -
Jan 22, 1990
filing date -
Oct 27, 1987
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Abstract
A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologous recombination occurs in the transfected cells leading to gene modification and the production of chimeric antibody molecules by the transfected cells.
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