Methods for controlling human endothelial cell proliferation and effector functions using oncostatin M
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United States of America Patent
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Apr 13, 1993
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N/A
app pub date -
Apr 10, 1989
filing date -
Apr 10, 1989
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Expired
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Abstract
The present invention is directed to the use of a recently discovered cytokine, Oncostatin M, to control endothelial cell immunogenicity, fibrinolytic activity and proliferation, and to its use in the treatment of a variety of human vascular and immune system disorders involving the vascular endothelium. The method of the invention includes the use of mature, hybrid, modified or truncated forms of Oncostatin M as well as Oncostatin M analogs. The invention is described by way of examples in which the efficacy of such compounds is evaluated using various in vitro assay systems.
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