Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
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United States of America Patent
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-
Apr 6, 1993
Issued Date -
N/A
app pub date -
Jan 31, 1991
filing date -
Mar 19, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
New retro-inverso analogs of thymopentin (TP5) and of its tripeptide fragment (TP5.sup.1-3) of general formula (I) ##STR1## are described wherein R is hydrogen or an acyl radical, and R.sup.1 is --OR.sup.2 or ##STR2## wherein R.sup.2 is hydrogen or a hydrocarbyl radical, and the corresponding pharmaceutically acceptable acid- or base-addition salts. A process of preparing the tripeptide fragment of formula I is also described. The new compounds are enzyme-resistant immunomodulatory peptides.
First Claim
all claims..Other Claims data not available
Family
Country | kind | publication No. | Filing Date | Type | Sub-Type |
---|---|---|---|---|---|
IT | B | IT1216908 | Mar 19, 1987 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
Patent | ANALOGHI RETRO-INVERSI DELLA TIMOPENTINA E DEI SUOI FRAMMENTI, IL METODO PER LA LORO SINTESI ED IL LORO IMPIEGO PER LA PREPARAZIONEDI COMPOSIZIONI FARMACEUTICHE. | Mar 14, 1990 | |||
EP | B1 | EP0282891 | Mar 09, 1988 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
Patent | New thymopentin retro-inverso analogs and fragments thereof, a process of preparation of the new compounds and the intermediates obtained therein | Jan 26, 1994 | |||
CA | C | CA1315472 | Mar 11, 1988 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
PATENT (PUBLISHED FROM 16.10.1990 ONWARDS) | THYMOPENTIN RETRO-INVERSO ANALOGS AND FRAGMENTS THEREOF, A PROCESS OF PREPARATION OF THE NEW COMPOUNDS AND THE INTERMEDIATES OBTAINED THEREIN | Mar 30, 1993 | |||
US | A | US5013723 | Mar 15, 1988 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
PATENT | New thymopentin retro-inverso analogs and fragments thereof, a process of preparation of the new compounds and the intermediates obtained therein | May 07, 1991 | |||
JP | A | JPS63250360 | Mar 18, 1988 | Patent | Application |
Type : Patent Sub-Type : Application | |||||
Published unexamined patent application | THYMOPENTIN RETRO-INVERSO ANALOGUE AND ITS FRAGMENT | Oct 18, 1988 | |||
CA | C | CA1336738 | Jan 13, 1992 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
PATENT (PUBLISHED FROM 16.10.1990 ONWARDS) | INTERMEDIATES PRODUCED DURING THE PREPARATION OF NEW THYMOPENTIN RETROINVERSO ANALOGS | Aug 15, 1995 |
- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
ENIRICERCHE S P A | VIA F MARITANO 26 S DONATO MIL SE (MI)- |
International Classification(s)

- 1991 Application Filing Year
- A61K Class
- 3434 Applications Filed
- 1462 Patents Issued To-Date
- 42.58 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Sisto, Alessandro | Rome, IT | 15 | 125 |
# of filed Patents : 15 Total Citations : 125 | |||
Verdini, Antonio S | Monterotondo, IT | 34 | 276 |
# of filed Patents : 34 Total Citations : 276 |
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Patent Citation Ranking
- 1 Citation Count
- A61K Class
- 10.81 % this patent is cited more than
- 32 Age
Forward Cite Landscape
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text

Legal Events
Date | Code | Event | Description |
---|---|---|---|
Jan 27, 2018 | STCH | INFORMATION ON STATUS: PATENT DISCONTINUATION | free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
Apr 09, 1997 | FP | LAPSED DUE TO FAILURE TO PAY MAINTENANCE FEE | Effective Date: Apr 09, 1997 |
Apr 06, 1997 | LAPS | LAPSE FOR FAILURE TO PAY MAINTENANCE FEES | |
Nov 12, 1996 | REMI | MAINTENANCE FEE REMINDER MAILED | |
Apr 06, 1993 | I | Issuance | |
Jan 31, 1991 | F | Filing | |
Mar 19, 1987 | PD | Priority Date |

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