Primary biliary cirrhosis autoantigen
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United States of America Patent
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Mar 23, 1993
Grant Date -
N/A
app pub date -
Sep 22, 1988
filing date -
Dec 16, 1986
priority date (Note) -
Expired
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Abstract
A DNA molecule is provided which comprises a nucleotide sequence substantially corresponding to all or a portion of the base sequence coding for the mitochondrial autoantigen of primary biliary cirrhosis. This DNA molecule may be linked to an expression control sequence. A synthetic peptide or polypeptide is provided which includes at least an amino acid sequence substantially as shown in FIG. 6 or FIG. 8. This synthetic peptide or polypeptide may be prepared by expression of a host cell which has been transformed with a recombinant DNA molecule as described above, or by chemical synthesis.
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