Sustained and controlled release of water insoluble polypeptides
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United States of America Patent
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Mar 9, 1993
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N/A
app pub date -
Sep 20, 1988
filing date -
Sep 21, 1987
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Expired
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Abstract
There is disclosed a pharaceutical composition for sustained and controlled release of drug over an extended period of time comprising a polylactide, a copolymer of lactic and glycolic acid, a mixture of such polymers and a water-insoluble peptide which, when placed in an aqueous physiologically-type environment releases the peptide in continuous manner for a period of at least one week, and with an initial release for the first twenty-four hours of not more than 30% of the total amount released. There is thus provided the control of the release pattern and in general a decrease of the initial burst effect.
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