Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
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United States of America Patent
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Mar 2, 1993
Issued Date -
N/A
app pub date -
Jun 26, 1991
filing date -
Feb 14, 1991
priority date (Note) -
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Abstract
Aerosol formulations for use in metered dose inhalers are disclosed which include 1,1,1,2-tetrafluoroethane alone and in combination with other compounds as well as various hydrocarbon blends. The density, vapor pressure, flame extension characteristics, dispersability of medicant, dissolvability of surfactant, respirable fraction, and compatibility elastomer seals for the aerosol formulations have been examined. The aerosol formulations are attractive alternatives to chlorofluorocarbon based aerosols since they do not deplete the ozone layer.
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