Monoclonal antibodies and antigen for human non-small cell lung carcinoma and other certain human carcinomas

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United States of America Patent

PATENT NO 5185432
SERIAL NO

06834172

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Abstract

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The present invention is concerned with novel monoclonal antibodies which bind strongly to a protein antigen associated with human non-small cell lung carcinomas ('NSCLC') human small cell lung carcinomas and certain other human carcinomas including many carcinomas of the colon and breast. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use both in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods for treatment of human in NSCLC and certain other human carcinomas. Also disclosed is a novel 110,000 dalton glycoprotein antigen found on the cell surface of human non-small lung carcinoma tumor cells and on cells from certain other human cancers. The amino terminal amino acid sequence of this antigen is: ##STR1## in which X represents an unidentified amino acid.

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Patent Owner(s)

Patent OwnerAddress
ONCOGEN A LIMITED PARTNERSHIP OF WASHINGTON3005 FIRST AVENUE SEATTLE WA 98121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brown, Joseph P Seattle, WA 39 1302
Hellstrom, Ingegerd Seattle, WA 44 1113
Hellstrom, Karl E Seattle, WA 23 829
Marquardt, Hans Mercer Island, WA 34 594

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