Method for chromatographic separation of synthetic phosphorothioate oligonucleotides
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United States of America Patent
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Feb 2, 1993
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N/A
app pub date -
Oct 18, 1991
filing date -
Oct 18, 1991
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Expired
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Abstract
A method is provided for the preparation and/or analysis or synthetic phosphorothioate and -dithioate oligonucleotides. In particular, the method permits separation of fully sulfurized phosphorothioate or -dithioate oligonucleotides from incompletely sulfurized defect species on strong-anion exchange HPLC columns using concentration gradients of novel 'soft base' anionic eluents, such as bromide, thiocyanate, and the like.
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