Adenosine compounds for the treatment of diseases caused by parasitic protozoa
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United States of America Patent
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Jan 19, 1993
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N/A
app pub date -
Oct 31, 1990
filing date -
Oct 31, 1990
priority date (Note) -
Expired
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Abstract
The compounds 5' -deoxy-5?-(hydroxyethylthio)adenosine (HETA); 5?-deoxy-5?-(monofluorethylthio)adenosine (MFETA); 5?-deoxy-5?-(chloroethylthio)adenosine (CETA); 5?-deoxy-5?-(bromoethylthtio)adenosine (BETA); 5-deoxy-5-(monofluoroethylthio)ribose (MFETR); 5-deoxy-5-(chloroethylthio)ribose (CETR); 5-deoxy-5-(bromoethylthio)ribose (BETR) and 5-deoxy-5-(hydroxyethylthio)ribose (HETR), are described as well as their uses in treating infections caused by 5?-deoxy-5?-methylthioadenosine (MTA) phosphorylase-containing pathogenic microorganisms; in treating infections caused by 5-deoxy-5-methylthioribose~ (MTR) kinase-containing pathogenic microorganism; and for treating neoplastic diseases.
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