Monoclonal antibody recognizing un-natural ganglioside GD3

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United States of America Patent

PATENT NO 5173420
SERIAL NO

07310654

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A monoclonal antibody A exhibits specificity to the sialic acid glycolipid containing the epitope NeuAc.alpha.2.fwdarw.9NeuAc terminal. A monoclonal antibody B exhibits specificity to the sialic acid glycolipid containing the epitope NeuAc.alpha.2.fwdarw.6Gal.beta. terminal. A monoclonal antibody C exhibits specificity to the sialic acid glycolipid containing at least one epitope selected from the group of NeuAc.alpha.2.fwdarw.9NeuAc terminal, NeuAc.alpha.2.fwdarw.6Gal.beta. terminal and NeuAc.alpha.2.fwdarw.1Cer. Hybridomas are prepared which produce antibodies A, B and C. A process for producing the hybridomas is disclosed including the step of fusing a myeloma cell and a B cell (lymphocyte) produced by the immunization of animal using as an antigen, the sialic acid glycolipid containing at least one epitope of the group NeuAc.alpha.2.fwdarw.9NeuAc terminal, NeuAc.alpha.2.fwdarw.6Gal.beta. terminal and NeuAc.alpha.2.fwdarw.1Cer.

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Patent Owner(s)

Patent OwnerAddress
MECT CORPORATION2-1-1 NISHI-SHINJYUKU SHINJYUKU-KU TOKYO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kannagi, Reiji Kyoto, JP 11 16
Kirihata, Yoshiko Kyoto, JP 2 3
Numata, Masaaki Kawagoe, JP 17 86
Ogawa, Tomoya Musashino, JP 112 962
Sugimoto, Mamoru Tokyo, JP 67 495

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