Pharmaceutical compositions
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United States of America Patent
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Dec 8, 1992
Grant Date -
N/A
app pub date -
Jan 4, 1989
filing date -
May 8, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides a solid pharmaceutical dosage form comprising: (i) cimetidine; and (ii) antacid, wherein at least part of the antacid is in the form of granules comprising a freely water-soluble solid diluent, the antacid, and a rapidly swellable water-insoluble disintegrant. Compositions of this type overcome the problem of the reduced bioavailability of cimetidine which can occur when cimetidine is co-administered with antacids.
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