3-cyano-5,4'-bipyridine-1'-oxide compounds and pharmaceutical compositions and methods containing the same
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United States of America Patent
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Nov 10, 1992
Grant Date -
N/A
app pub date -
Mar 7, 1991
filing date -
Mar 9, 1990
priority date (Note) -
Expired
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Abstract
A 3-cyano-5,4'-bipyridine-1'-oxide of the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R is an amino, alkoxy, oxyalkoxy or chloro residue, have heart stimulating cardiotonic and vasodiolatory properties. They can be preparaed by (a) converting an R-substituted-3-cyano-bipyridine to its corresponding N-oxide, or (b) by substituting an R-residue or an R-unsubstituted precursor of the conpound of fomula (i), and if required, converting the product into its pharmaceutically acceptable acid addition salt.
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