ACAT inhibitory benzanilides
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United States of America Patent
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Oct 27, 1992
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N/A
app pub date -
Aug 5, 1991
filing date -
Sep 27, 1989
priority date (Note) -
Expired
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Abstract
Benzanilide derivatives of the formula: ##STR1## wherein R.sup.1 is alkyl optionally containing double or triple bonds, and optionally interrupted by one or more hetero atoms; R.sup.2 is hydrogen, methyl, or ethyl; R.sup.3 is halogen, alkyl, --OY, --SY, or dimethylamino; R.sup.4 and R.sup.5 are hydrogen, alkyl optionally containing double or triple bonds, or --(CH.sub.2).sub.m --Z, wherein: Z is --OCH.sub.3, --SCH.sub.3, --N(CH.sub.3).sub.2 or alkanoylamino, and m is 2, 3 or 4; X is oxygen, --OCH.sub.2 --, --S--, --SCH.sub.2 -- or --NR.sup.6 --; R.sup.6 is hydrogen, methyl, ethyl, or acyl; and Y is alkyl; are useful as anti-atherosclerotic agents.
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