Covalent lipid-drug conjugates for drug targeting
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United States of America Patent
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Sep 22, 1992
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N/A
app pub date -
Nov 1, 1990
filing date -
Nov 1, 1990
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Expired
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Abstract
This invention relates to a novel method of drug targeting which comprises covalently binding a drug to a lipid carrier. This composition has the unique ability to both enhance the rate at which an antineoplastic or antiviral drug crosses the plasma membrane, and to direct the drug within the cell to specific organelles. The versatility of these conjugates may be further enhanced by including a spacer group between the drug and the lipid which may act to modulate drug release at the target site.
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