Thiazolidine derivatives with anti-diabetic activity, their preparation and their use

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United States of America Patent

PATENT NO 5143930
SERIAL NO

07645108

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Abstract

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Compounds of formula (I): ##STR1## in which: A is a group of formula (II) or (III): ##STR2## W is methylene, carbonyl or >C.dbd.N--OV, where V is hydrogen, sulfo, acyl or alkyl; U is methylene, or W is absent and U is a carbon-carbon double bond between A and --CR.sup.1 (OH)--; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each hydrogen or alkyl; Y.sup.1 and Y.sup.2 are each hydrogen or a hydroxy-protecting group; and n is 1, 2 or 3 and salts thereof have anti-diabetic activity in mammals. Methods of preparing them are also provided.

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Patent Owner(s)

Patent OwnerAddress
SANKYO COMPANYLIMITED 5-1 NIHONBASHI-HONCHO 3-CHOME CHUO-KU A CORP OF JAPAN TOKYO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fujita, Takashi Tokyo, JP 383 4821
Horikoshi, Hiroyoshi Tokyo, JP 34 380
Kanai, Tsutomu Tokyo, JP 16 353
Kinoshita, Takeshi Tokyo, JP 35 120
Nakamura, Kanichi Tokyo, JP 2 21
Sasahara, Kunihiro Tokyo, JP 1 10
Yoshioka, Takao Tokyo, JP 49 606

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