Monoclonal antibodies capable of recognizing gangliosides GQ.sub.1b and GT.sub.1a
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United States of America Patent
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Aug 25, 1992
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N/A
app pub date -
Jul 10, 1989
filing date -
Jul 16, 1988
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Abstract
A monoclonal antibody specifically recognizes an epitope or an antigenic determinant represented by the following formula and specifically reacts therewith: ##STR1## The monoclonal antibody can be obtained by cultivating hybridoma cells which can be generated by a method comprising cell-fusing (A) B cells or lymphocytes obtained by immunizing an animal with a substance involving the epitope or the antigenic determinant represented by the foregoing formula and (B) myeloma cells. The monoclonal antibody shows high specificity to ganglioside GQ.sub.1b and ganglioside GT.sub.1a having a specific epitope and thus can detect the epitope in high sensitivity. Therefore, the antibody can be used for the elucidation of sugar chain's roles in cell functions and for studying the development of animals. Moreover, the monoclonal antibody would have various clinical applications.
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