Process for solubilizing difficulty soluble pharmaceutical actives
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United States of America Patent
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Aug 25, 1992
Grant Date -
N/A
app pub date -
Jun 27, 1991
filing date -
Jun 27, 1991
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to a process for solubilizing at least one difficultly soluble pharmaceutical active in a mixture of polyethylene glycol and polyvinylpyrrolidone. The process does not require water as a solvent or the use of a heating step. In further embodiments, the present invention also relates to a process for encapsulating these solubilized pharmaceutical compositions within soft gelatin shells, which are preferably transparent. Both the resulting compositions and their capsules provide an effective means for oral delivery of a wide variety of difficultly soluble pharmaceutical actives.
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