Detection of lymphocyte amplification
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United States of America Patent
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May 12, 1992
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app pub date -
Apr 13, 1989
filing date -
Jun 22, 1987
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Abstract
A method for detecting lymphocyte clonal amplification in a mammal by cloning of lymphocytes so as to identify cell lines expressing a mutation at a structural locus and determining the structure of the antigen receptor in the mutated clonal cell lines. Similar rearrangements of the regions of nucleic acid encoding antigen receptor among multiple isolated clones from a single individual indicate an in vivo clonal lymphocyte amplification event.
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