Pharmaceutical composition comprising a spiro oxathiolon/quinuclidine and method of treating senile dementia

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United States of America Patent

PATENT NO 5106831
SERIAL NO

07599977

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Abstract

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A pharmaceutical composition is disclosed comprising (-)-cis-2-methylspiro(1,3-oxathiolan-5,3')quinuclidine, and/or the pharmaceutically compatible acid addition salts thereof, together with at least one of physostigmine, tetrahydroaminoacridine, choline, lecithin, piracetam, aniracetam, pramiracetam, oxiracetam, 4-aminopyridine, 3,4-diaminopyridine, somatostatin, pirenzepine, N-methylatropine, N-butylscopolamine, scopolamine, clonidine, quanfamicine and Nerve Growth Factor. Also disclosed is a method for treating senile dementia of Alzheimer's type, which comprises coadministering to a patient in need thereof an effective dose of the spiro compound together with at least one other compound selected from those listed above.

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Patent Owner(s)

Patent OwnerAddress
STATE OF ISRAEL REPRESENTED BY THE PRIME MINISTER'S OFFICE ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCHPOB 19 NESS ZIONA 70450

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fisher, Abraham Holon, IL 43 598
Grunfeld, Yona Rehovot, IL 3 60
Heldman, Eliahu Rehovot, IL 21 156
Karton, Ishai Ness-Ziona, IL 5 69
Levy, Aharon Beit Hanan, IL 9 210

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