High ibuprofen content granulations
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United States of America Patent
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-
Apr 14, 1992
Issued Date -
N/A
app pub date -
Jan 11, 1990
filing date -
Feb 2, 1989
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A granular pharmaceutical composition containing 85 to 99 percent ibuprofen, 0.9 to 15.0 percent binder, and 0.1 to 5.0 percent polyvinylpyrrolidone, wherein the polyvinylpyrrolidone forms a film with a portion of said binder to form agglomerates, is disclosed. Ibuprofen may be fluidized with a portion of the binder in a fluid bed apparatus and sprayed with an aqueous dispersion of polyvinylpyrrolidone and the remainder of the binder. This granulation may be subsequently blended with additional excipients and, optionally, additional active pharmaceutical ingredients for direct compression into tablets.
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