Method for preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepine-4-one and chlorinated derivatives thereof

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United States of America Patent

PATENT NO 5102998
SERIAL NO

07426285

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Abstract

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2-Aminothiophenol is reacted with methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate, and the intermediate methyl (2S,3S)-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)propionate is cyclized in the presence of methanesulfonic acid, in the same vessel and without isolating said intermediate product, using e.g. chlorobenzene as a solvent.

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Patent Owner(s)

Patent OwnerAddress
SYNTHELABO22 AVENUE GALILEE LE PLESSIS-ROBINSON 92350

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bourbon, Andre Mantes La Jolie, FR 5 12
Chekroun, Isaac Epinay, FR 17 44
Graux, Jean-Baptiste Mantes La Ville, FR 3 8
Rossey, Guy Voisins-Le-Bretonneux, FR 21 65
Ugolini, Antonio Le Pecq, FR 17 137
Wick, Alexander St. Nom La Breteche, FR 19 104

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