Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents
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United States of America Patent
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Apr 7, 1992
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Oct 31, 1989
filing date -
Oct 31, 1989
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Abstract
The pyrimidine biosynthesis inhibitors dichloroallyl lawsone, N-(phosphonoacetyl)-L-aspartic acid (PALA), pyrazofurin, and derivatives thereof, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing these compounds are useful for the treatment of autoimmune diseases, chronic inflammatory diseases, and of organ transplantation rejections.
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