Pharmacologically active amides and esters containing an azabicycloalkane moiety
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United States of America Patent
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Mar 17, 1992
Grant Date -
N/A
app pub date -
Oct 10, 1990
filing date -
Oct 14, 1989
priority date (Note) -
Expired
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Abstract
Compounds of formula ##STR1## wherein R.sup.1 is hydrogen or one or more specified substituents, X is --O-- or --NR.sup.2 -- where R.sup.2 is lower alkyl, lower alkenyl, lower alkynyl, aryl or specified substituted lower alkyl or R.sup.2 represents a group --Z-- which is connected to the 8-position of the aromatic ring so as to form a heterocyclic ring of 5 to 7 ring members, Y is O or NR.sup.3 where R.sup.3 is hydrogen or lower alkyl, and B is a saturated azabicyclic ring (eg tropanyl or quinuclidinyl) or a N-oxide thereof and their acid addition salts are 5-HT.sub.3 antagonists which may be used in, for example, the treatment of neuro-psychiatric disorders.
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