Retro-inverso analogues of thymopentin, and their use in the preparation of pharmaceutical compositions
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United States of America Patent
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Feb 25, 1992
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N/A
app pub date -
Dec 21, 1989
filing date -
Dec 23, 1988
priority date (Note) -
Expired
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Abstract
New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP5.sup.1-4) containing two non-contiguous retro-inverted bonds in the peptide chain are described. The new compounds, of general formula (I) ##STR1## where R is hydrogen or an acyl radical, and R.sup.1 is an --OR.sup.2 group or an ##STR2## group where R.sup.2 is a hydrogen atom or a hydrocarbon radical, and R.sup.3 is a hydrogen atom or a hydroxyl group, and the corresponding pharmaceutically acceptable salts of acid or basic addition, possess immunomodulating activity.
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