Method of isolating ginkgolides from the leaves of the ginkgo tree and purifying them
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United States of America Patent
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Feb 18, 1992
Grant Date -
N/A
app pub date -
Jun 15, 1990
filing date -
Jun 16, 1989
priority date (Note) -
Expired
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Abstract
A method of isolating ginkgolides from the leaves of the Ginkgo tree which is characterized by a series of steps as follows: (a) Adjusting the pH of an aqueous solution of an extract of the leaves of the Ginkgo tree to the range of 7 to 9 by adding an alkaline aqueous solution, (b) Extracting the aqueous solution treated as above with lower acetates, lower ketones or benzenes, separate the solution into a layer of aqueous solution and a layer of organic solvent, dehydrating and drying the layer of organic solvent, and obtaining a powder, (c) Adjusting the pH of the layer of aqueous solution separated in step (b), to the range of 1 to 3 by adding an acidic aqueous solution, extracting the layer of aqueous solution treated as above with lower ethers or chloroforms, dehydrating and drying the obtained extract, (d) Dissolving the dry powder obtained the step (b) and the residue obtained in the step (c) in a lower alcohol, (c) Adding an aqueous solution of lead acetate to the solution obtained in the step (d), removing the precipitate, concentrating the filtrate, and obtaining a powder mixture of ginkgolides.
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