Azulene derivatives as thromboxane A.sub.2 and prostaglandin endoperoxide receptor antagonist
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United States of America Patent
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Jan 14, 1992
Grant Date -
N/A
app pub date -
Jun 26, 1990
filing date -
Jul 5, 1989
priority date (Note) -
Expired
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Abstract
A series of new azulene analogues are disclosed, which are represented by the following formula: ##STR1## wherein: R.sub.1 is --COOH, --COOR.sub.4 (R.sub.4 represents a lower alkyl), --CH.dbd.CH--COOH, --CH.sub.2 --COOH or --SO.sub.3 H; R.sub.2 is a hydrogen atom or lower-alkyl group; R.sub.3 is a hydrogen atom, a lower alkyl or benzyl group; A is --SO.sub.2 --, ##STR2## (R.sub.5 represents a lower alkyl); B is a phenyl, a lower alkylphenyl, a lower alkoxyphenyl, nitrophenyl, trifluoroalkylphenyl, mono-or di-halogenated-phenyl, naphthyl or tetrahydroaphthyl group; Y is an alkylene or alkenylene group. The compounds of the present invention are useful as thromboxane A.sub.2 and prostagrandin endoperoxide receptor antagonists.
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