Human IL-1 cDNA sequences encoding biologically-active human IL-1 proteins
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United States of America Patent
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Dec 31, 1991
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app pub date -
Aug 21, 1990
filing date -
May 18, 1984
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Abstract
The subject invention concerns truncated human Il-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.
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