Encapsulation of antineoplastic agents in liposomes
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United States of America Patent
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Dec 31, 1991
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N/A
app pub date -
Dec 12, 1988
filing date -
Aug 8, 1984
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Expired
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Abstract
Methods for encapsulating ionizable antineoplastic agents in liposomes using transmembrane potentials are provided. Trapping efficiencies approaching 100% and rapid loading are readily achieved. Dehydration protocols which allow liposomes to be conveniently used in the administration of antineoplastic agents in a clinical setting are also provided. In accordance with other aspects of the invention, transmembrane potentials are used to reduce the rate of release of ionizable drugs from liposomes.
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