Enkephalin analogs
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United States of America Patent
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Oct 29, 1991
Grant Date -
N/A
app pub date -
Aug 23, 1988
filing date -
Aug 24, 1987
priority date (Note) -
Expired
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Abstract
The invention relates to enkephalin analogs of the formula ##STR1## wherein in case of X is D-Val, D-Phe, Pro, D-Met, D-Met(O), D-Leu, D-Glu, D-Glu(Obzl), D-Lys, D-Lys(Z), or D-Arg, Y is Gly or Phe; and R is a) a direct bond, b) an alkylene group having from 1 to 6 carbon atoms, c) o-, m-, or p-phenylene group, d) a cycloalkane; or wherein in case of X is D-Ala, Y is Phe; and R is a) a direct bond, b) an alkylene group having from 1 to 6 carbon atoms, c) o-, m-, or p-phenylene group, or d) a cycloalkane, its salts and hydrates, as well as a therapeutic composition containing at least one of the enkephalin analogs, as an effective component.
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