Topically active ocular benzothiazole sulfonamide carbonic anhydrase inhibitors
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United States of America Patent
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Oct 22, 1991
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N/A
app pub date -
Mar 19, 1990
filing date -
Mar 19, 1990
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Expired
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Abstract
This invention is directed to compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.6 is hydrogen or lower alkyl; each R.sub.1 is hydrogen, lower alkyl, halogen, nitro, trihaloalkyl, lower alkoxy, formyl, lower alkanoyl, loweralkylamino or diloweralkylamino ##STR2## X is O, S or NR.sub.5 ; R.sub.2 is OR.sub.7 or NR.sub.7 R.sub.8 ; each R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl; R.sub.5 R.sub.7 and R.sub.8 are independently hydrogen or lower alkyl; n is 0-3 and m is 0-6. These compounds are useful for treating glaucoma or assessing corneal function in mammals.
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