Topically active ocular gem-diacylthiadiazole sulfonamide carbonic anhydrase inhibitors
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United States of America Patent
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Oct 8, 1991
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N/A
app pub date -
Mar 19, 1990
filing date -
Mar 19, 1990
priority date (Note) -
Expired
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Abstract
This invention relates to compounds of the following formula useful as a carbonic anhydrase inhibitor: A compound of the formula: ##STR1## and pharmaceutically acceptable salts thereof wherein X is NR.sub.12 ; R.sub.1 is ##STR2## R.sub.2 is ##STR3## R.sub.3 is hydrogen or lower alkyl; R is hydrogen or lower alkyl; each R.sub.4 and R.sub.5 are independently hydrogen or lower alkyl; each R.sub.7 and R.sub.8 are independently hydrogen or lower alkyl; R.sub.6 is OR.sub.10 or NR.sub.10 R.sub.11 ; R.sub.9 is OR.sub.13 OR NR.sub.11 R.sub.13 ; R.sub.10, R.sub.11 R.sub.12, and R.sub.13 are independently hydrogen or lower alkyl; and n and m are independently 0-6.
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