High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
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United States of America Patent
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Sep 10, 1991
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N/A
app pub date -
Dec 18, 1987
filing date -
Jan 27, 1987
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Expired
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Abstract
Plasmid pUC8 and DNA coding for hIL-1.beta. are used to construct hybrid plasmids capable of high level expression in E. coli of soluble proteins, including mature hIL-1.beta. and derivatives of mature hIL-1.beta. having amino acid substitutions and insertions at one or all of positions 1 to 4 at the amino terminus. Derivatives of hIL-1.beta. with alterations at the N-terminus have been produced which have either enhanced or decreased bioactivity compared to native monocyte derived hIL-1.beta..
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