Importance

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Abstract

Compounds of formula I, and pharmaceutical compositions containing compounds of formula I ##STR1## wherein: R.sub.1 is: (a) COCH.sub.3, COC.sub.6 H.sub.5, CN or NO.sub.2 ; (b) COORa wherein Ra is hydrogen, or optionally substituted C.sub.1 -C.sub.6 straight or branched alkyl; R.sub.2 is optionally substituted phenyl; pentafluorophenyl; .alpha.- or .beta.-naphthyl; a five- or six-membered heterocyclic ring; .alpha.-benzo[2,3-b]-1,4-dioxan-.alpha.-yl; or .alpha.-benzofuroxanyl; R.sub.3 is COORa; P is hydrogen, --(CH.sub.2).sub.p --W, or C.sub.1 -C.sub.8 linear or branched alkyl; N--P.sub.1 is the residue of a primary or secondary amino group wherein P.sub.1 is hydrogen, C.sub.1 -C.sub.6 lower linear or branched alkyl group, or --(CH.sub.2).sub.p --W; and P, taken together with P.sub.1 and the nitrogen atom to which P.sub.1 is linked, may form a pyrrolidine or a piperidine ring; W is hydroxymethyl, formyloxymethyl, CO.sub.2 R wherein R is hydrogen or C.sub.1 -C.sub.4 lower alkyl, CN, saturated or unsaturated heterocyclic ring, C.sub.3 -C.sub.7 cycloalkyl ring, or optionally substituted phenyl; m is an integer from 1 to 3; n is zero or an integer from 1 to 2; p is zero or an integer from 1 to 3. The compounds of formula (I) and compositions containing them are effective in anti-hypertensive therapy.

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First Claim