Non-ionic contrast media from ionic contrast media
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United States of America Patent
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Jul 30, 1991
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N/A
app pub date -
Sep 14, 1990
filing date -
Aug 9, 1985
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Abstract
Novel non-ionic contrast media are efficiently prepared from generally available ionic contrast media. Particularly, polyhydroxyhalohydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.
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