Process for the preparation of cytosines
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United States of America Patent
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Jun 25, 1991
Grant Date -
N/A
app pub date -
Jan 3, 1990
filing date -
Mar 3, 1989
priority date (Note) -
Expired
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Abstract
Cytosines which may optionally be substituted in the 5 position are prepared by a simplified process in which urea is reacted with an alcoholate and an alkoxy-acrylonitrile or dialkoxy-propionitrile in a sparsely water-miscible organic solvent which is inert under the reaction conditions. The use of such a solvent makes it possible to react the mentioned reactants in simple fashion without isolation of an intermediate stage, and to reuse the organic solvent without a separate purification.
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