Expression cDNA clones encoding antigens of onchocerca volvulus
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United States of America Patent
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Jun 4, 1991
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N/A
app pub date -
Jun 30, 1988
filing date -
Jun 30, 1988
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Expired
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Abstract
A cDNA clone (.lambda.RAL-1) that encodes a protein with an apparent molecular weight of 42,000 in vivo and which clone binds with O. volvulus antisera. A recombinant antigen produced by the aforementioned clone, which antigen stimulates T cells from infected individuals to proliferate. A DNA which codes for an O. volvulus peptide sequence, the sequence containing three repeats of the polypeptide sequence KKPEDWD.
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